Cast-in-place concrete frames support a light steel roof structure, sheathed with translucent fabric canopies, making architecture out of infrastructure. Elevated pedestrian concourses link two parallel bus bays and the Metrorail station while bridging Fannin Street. PDG Architects designed the Metro-rail station; Alan Krathaus and Fiona McGettigan of CORE Design produced the public art installation on the history of medical breakthroughs.
Across the street from the transit center at 1825 Pressler Street is the Fayez S. Sarofim Research Building of the University of Texas Health Science Center at Houston of 2006 by Berkebile Nelson Immenschuh McDowell, designed to meet strict sustainability criteria.