The third building for Jackson’s oldest Catholic congregation, this imposing Gothic Revival brick church was the first Mississippi project for Weathers and the largest to that time for contractor William J. McGee (c. 1854–1943), a member of the congregation. The symmetrical facade is dominated by a central entrance tower that rises through two stages to an octagonal spire flanked by pinnacles. In 1959, the stained glass window over the entrance was replaced with a glass mosaic, Christ the Good Shepherd, designed by Emil Frei of St. Louis and executed by the Orsoni Workshop of Venice. A parish hall addition is at the rear.
The church is part of a complex that for the first half of the twentieth century included a convent and school. Across Amite Street is the Colonial Revival rectory (1921, Theodore C. Link). Behind it, the three-story red brick Diocesan Chancery Office (1947–1948, James T. Canizaro) marks the transfer of the seat of the diocese from Natchez to Jackson in 1948. The chancery’s Georgian Revival styling is unusual for Canizaro, who is best known for modernist designs.